PDC Half Life Prediction

Only supports single-chain small-molecule peptides (AA: 2-50).

SMILES must be provided for both modified and natural peptides, as this format enables representation of peptides with any type of modification.
Natural peptides or those with simple modification can obtain SMILES using:

PepSMI
Convert basen on ChemAxon

Complex modified peptides require a structure editor to generate SMILES.

Step 1: input peptide + linker + payload SMILES.

Payload SMILES

Example PDC: DTS-108 payload SMILES

Linker SMILES

Example PDC: DTS-108 linker SMILES

PDC SMILES

Example PDC: DTS-108 PDC SMILES

Step 2: input peptide sequence.

Peptide sequence

Load sequence: DTS-108 peptide sequence
The sequence is used to generate a fresh ESM-2 embedding before PDC half-life prediction.

If the peptide is modified, only enter the corresponding natural peptide sequence here; modification information is conveyed through the SMILES input.

SMILES drawer

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